This workshop aims to bridge the two different disciplines of biophysics and dynamic structural biology, covering time-resolved spectroscopic (optical and vibrational spectroscopy) and X-ray techniques (crystallography and scattering at synchrotrons and XFELs). The synergy of the experimental techniques will be complemented by computational approaches. Particular attention will be given to fostering collaborations between experts from these different areas and to the training of young researchers. To that end the lectures will have a strong educational element including training sessions with hands-on experience in the analysis of time-resolved spectroscopic and crystallographic data.
The following topics will be covered: time-resolved spectroscopy (infrared, Raman, circular dichroism, fluorescence), time-resolved serial crystallography at synchrotrons and XFELs, time-resolved cryo EM, fast-mixing techniques, sensory photoreceptors of optogenetic interest, rhodopsins, heme proteins, flavoproteins, cryptochromes, LOV domains, BLUF domains, UV-damage, computational biology (MD simulations, DFT, QM/MM), photophysics, membrane proteins, photosynthetic systems and software development for serial crystallography.
Organizers: Sofia Maria Kapetanaki, András Lukács, Giorgio Schirò, Sofia Jaho